|
| |
|
|
| [ 文章来源： | 文章作者：
| 发布时间：2006-12-25|
字体：
[大
中
小]
| |
|
December 21, 2006
封面故事：与肥胖有关的肠道微生物
肠道微生物可以帮助我们完成我们本身不能完成的一些代谢任务。从某种意义上来说，它们的基因是智人（Homo sapiens）“多源基因组”（metagenome）的一部分。本期两篇相关的论文帮助说明了这一点，它们为微生物在肥胖的形成中所起的作用提供了证据。对肥胖者肠道中两组占主导地位的细菌的含量多少所做的一项研究工作表明，Bacteroidetes细菌数量的增加与体重降低相关联。对遗传性肥胖的小鼠所做的一项研究显示，与同窝出生的瘦的小鼠相比，它们肠道微生物群落利用能量的能力要强一些，而将该微生物群落移植进肠道中没有细菌的小鼠体内时，这种性状也能被转移过去。这项工作说明，与肥胖相关的肠道微生物也许是一种生物标记，并且可能是一个治疗目标。
December 21, 2006
抗VEGF疗法的一种替代疗法
VEGF（血管内皮生长因子）是得到最好定性的肿瘤血管形成诱发因子，阻断VEGF的功能已经成为癌症治疗中的一个重要工具。但VEGF的阻断并不是对所有肿瘤都有效，所以寻找替代方法的工作在继续。两个小组在本期Nature上报告，其中的一个这种替代方法可能是DII4（即Delta-like ligand 4）的阻断。该跨膜分子是Notch信号作用通道的一部分。过去人们知道它是胚胎中血管正常发育所必需的，而新的研究工作表明，肿瘤血管形成也需要它。它可能是患有对抗VEGF疗法有抵抗力的固体肿瘤的患者的一种可行的、耐受性可能比较好的替代疗法。
December 21, 2006
关于衰老过程的两个理论可能是一致的
此前，人类XPF基因的突变一直被与温和型的早衰（progeria）联系在一起。现在，研究人员在一个15岁的男孩身上识别出了一个以前不知道的、引起严重早衰的XPF突变（XFE）。XPF的这一突变体形式的性质表明，两个关于衰老过程的看似根本不相同的理论可能是一致的。 有些人认为，衰老是由基因调控的；另一些人认为，衰老是由于DNA损伤的逐渐积累。这两种观点可能都是正确的。被研究人员用遗传工程方法来模拟这种症状的年轻小鼠，表现出正常年老小鼠的很多特征。这些特征包括诱导产生的胰岛素信号作用、细胞死亡增加、以及高抗氧化剂水平和高DNA修复活性。这些发现与DNA损伤来自与衰老相关的功能下降的一个模型是一致的，但遗传学规律（尤其是对胰岛素信号通道而言）影响损伤积累的速度有多快以及功能损失的速度有多快。该发现的一个意义是，通过增强DNA修复体系，也许有可能延长寿命或改善老年时的身体适应性。
December 21, 2006
GRB需要新的分类体系
将伽马射线爆（GRB）分成长爆（持续时间超过两秒）和短爆的分类体系可能已经完成了其使命，而宣布该体系终结的可能是GRB 060614。这个伽马射线爆是2006年6月14日由搭载在Swift卫星上的Burst Alert天文望远镜发现的，属于长爆，持续时间为102秒，但正如本期Nature上一组论文所报告的那样，它所具有的若干性质（包括缺少一个相伴的超新星）以前被认为是短GRB的典型特征。所以，研究人员现在正在寻找一个能将目前在GRB中明显看到的这种多样性考虑进去的一个分类体系。在配发的一篇News & Views文章中，P. R. W. Zhang提出，答案可能是采用一种将GRB分成两类的分类体系，即将其分成一类GRB和二类GRB，该体系与用于超新星分类的分类体系相似。
December 21, 2006
关于水星磁场的新模型
地球磁场的行为可以用关于所谓的“地球发电机”（geodynamo）的最新数值模型来很好地模拟，而对其他行星，要进行这种模拟则比较困难。同地球一样，水星也有一个双极磁场，很可能是由该行星液体铁质内核中对流形成的一个发电机体系产生的。但水星的磁场要比地球的磁场弱上百倍，对发电机理论来说，这便成了一个问题。研究人员对这种偏差已经提出了一个新的解释，该新理论既解释了所观测到的磁场强度，也解释了由“水手号”飞船10次掠过水星时所观测到的该磁场的几何特征。这一新模型假设水星的“发电机”只在内核深层“发电”，产生一个强磁场。内核外围区域是稳定分层的，所以不对流热，但却是导电的，由“发电机”所产生的磁场在向外穿透时受到电磁表层效应的强烈阻尼。来自正在飞往水星途中的美国国家航空航天局（NASA）MESSENGER探测器的关于水星磁场的数据以及欧洲航天局（ESA）计划执行的BepiColombo探测任务，应能对这一模型进行彻底的验证。
December 21, 2006
自由中子放射性贝塔衰变的实验测量
中子的放射性贝塔衰变产生一个质子、一个电子和一个反中微子。量子电动力学预测，一个由软质子构成的连续波谱应伴随这些衰变产物。这种辐射以前曾在核贝塔和电子捕获衰变中被测量过，但却没有在自由中子衰变中被测量过。现在，在位于美国马里兰州Gaithersburg的“美国国家标准与技术研究所”的NG-6（即Neutron Guide 6）装置上所进行的一个实验中，研究人员已经观测到了自由中子的放射性贝塔衰变，并且产生了质子。所获得的测量结果与理论是一致的。这一进展也许可为更深入地研究中子贝塔衰变中所涉及的弱相互作用过程提供机会。
December 21, 2006
南极潮汐变化与冰流速度的关系
像南极洲的那种冰层会通过快速流动的冰流失区其大部分冰。Hilmar Gudmundsson对这样一个冰流中的流动情况进行了为期两个月的监测，它就是南极洲西部的拉特福德冰流。他所获得的发现是令人吃惊的：这里的表层流速在两个星期时间里波动高达20%，也许是受春季小潮为期两周的潮汐周期的影响。虽然将这些潮汐变化与冰流耦合到一起的机制尚不清楚，这些观测结果也说明，在有限时期内利用速度测量结果来推断流速长期变化是要谨慎的。
December 21, 2006
同性之间生殖机会竞争规律的一个例外
在其后代中投入最少的一个性别往往能够形成更为明显的第二性征，在争夺异性方面也竞争得最激烈。对海猫所做的一项为期12年的研究工作，让我们看到了一种动物，它们是这一规则的一个例外。虽然雌性海猫比雄性海猫在其后代中投入要多，但它们会更强烈地去争取生殖机会；影响竞争成功与否的性状对其生殖成功与否有更强影响；而且它们还表现出与生殖竞争相关的第二性状发育更多。这种异常行为的根源可能是这样一个事实：雌性的成功生殖所需资源是高度集中的，并且还可能是稀缺的，所以同性之间对繁殖机会的竞争在雌性当中与在雄性当中相比同样受重视或者更受重视。
December 21, 2006
南极潮汐变化与冰流速度的关系
像南极洲的那种冰层会通过快速流动的冰流失区其大部分冰。Hilmar Gudmundsson对这样一个冰流中的流动情况进行了为期两个月的监测，它就是南极洲西部的拉特福德冰流。他所获得的发现是令人吃惊的：这里的表层流速在两个星期时间里波动高达20%，也许是受春季小潮为期两周的潮汐周期的影响。虽然将这些潮汐变化与冰流耦合到一起的机制尚不清楚，这些观测结果也说明，在有限时期内利用速度测量结果来推断流速长期变化是要谨慎的。
December 21, 2006
神经元启动活动势的启动点
不同神经元在其轴突上的不同点上启动其活动势，但这种现象在功能上有什么意义却不清楚。Kuba等人对一种鸟类的听觉系统中的神经细胞进行了专门研究：Nucleus laminaris是一种双耳重合探测器，是研究这一现象的一个很好的模型。他们发现，诱发靠近细胞体的活动势的神经元接听频率较低的声音。电脑模拟显示，活动势的启动点可能也是其他神经元进行重合探测的关键。
Contents
Editorials
Kyoto for commuters p971
Offset schemes are a small but potentially useful addition to the carbon balance sheet.
doi:10.1038/444971a
Full Text | PDF (91K)
--------------------------------------------------------------------------------
Peer review and fraud p971
Two assessments of the refereeing process highlight challenges for journals.
doi:10.1038/444971b
Full Text | PDF (126K)
--------------------------------------------------------------------------------
Days of Futures past p972
It's a time of change for Nature's venture into speculative fiction.
doi:10.1038/444972a
Full Text | PDF (78K)
--------------------------------------------------------------------------------
Top of pageResearch Highlights
Research highlights p974
doi:10.1038/444974a
Full Text | PDF (272K)
--------------------------------------------------------------------------------
Top of pageNews
Climate credits p976
Why change your lifestyle when you can pay a company to save your greenhouse-gas emissions for you? Quirin Schiermeier investigates whether carbon offsetting can really save the planet.
doi:10.1038/444976a
Full Text | PDF (380K)
--------------------------------------------------------------------------------
Green activists enlist penguins to save the world p978
Environmentalists hail 'Happy Feet effect'.
Katie McGoldrick and Emma Marris
doi:10.1038/444978a
Full Text | PDF (225K)
--------------------------------------------------------------------------------
Gravity probe falters p978
Instrumentation problems leave relativity test in the balance.
Geoff Brumfiel
doi:10.1038/444978b
Full Text | PDF (225K)
--------------------------------------------------------------------------------
Animal experiments under fire for poor design p981
Critics say trials do not translate well into human studies.
Jim Giles
doi:10.1038/444981a
Full Text | PDF (162K)
--------------------------------------------------------------------------------
Sidelines p982
doi:10.1038/444982a
Full Text | PDF (124K)
--------------------------------------------------------------------------------
NIH offers free access to wealth of disease data p982
Project aims to mine information on genotypes, phenotypes and lifestyle.
Gene Russo
doi:10.1038/444982b
Full Text | PDF (124K)
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
Correction p983
doi:10.1038/443983b
Full Text | PDF (168K)
--------------------------------------------------------------------------------
News in brief p983
doi:10.1038/444983a
Full Text | PDF (168K)
--------------------------------------------------------------------------------
Top of pageNews
2006 Gallery: Brilliant display p985
From a jewel-like bird, rarer than any diamond, to the delicately poetic swirls generated inside aircraft engines, the pursuit of knowledge turns up its fair share of beauty. This issue, Nature wraps up the year with an arresting series of images from 2006. We've divided them into the art of the natural world, planet-scapes both domestic and extraterrestrial, and the splendour of modern technology. Just because something enhances our knowledge doesn't mean it can't also be bewitching.
Emma Marris
doi:10.1038/444985a
Full Text | PDF (3,079K)
--------------------------------------------------------------------------------
Top of pageBusiness
Better, faster - and easier to use p993
The Pentagon is sinking millions of dollars into developing the next generation of supercomputers — and plans to let non-military scientists and engineers share the benefits. Heidi Ledford reports.
doi:10.1038/444993a
Full Text | PDF (124K)
--------------------------------------------------------------------------------
Top of pageNews Features
Human evolution: How Africa learned to love the cow p994
The development of lactose tolerance in sub-Saharan Africa is a fascinating tale of genetic convergence, reports Erika Check.
doi:10.1038/444994a
Full Text | PDF (1,172K)
--------------------------------------------------------------------------------
Oceanography: Creating the perfect wave p997
Kerry Black travelled the world in search of the best surf spots. Then he decided to build them himself — on land. Mark Schrope meets the maverick oceanographer.
doi:10.1038/444997a
Full Text | PDF (960K)
--------------------------------------------------------------------------------
Physiology: Freaks of nature? p1000
Ultraendurance racers torture their bodies and minds to achieve near-impossible physical feats. Is it an exceptional genetic make-up or the vestiges of human evolution? Helen Pearson reports.
doi:10.1038/4441000a
Full Text | PDF (516K)
See also: Editor's summary
--------------------------------------------------------------------------------
Top of pageCorrespondence
Life: perhaps we should take the porridge theory with a pinch of salt p1002
Peter Wigley
doi:10.1038/4441002a
Full Text | PDF (77K)
--------------------------------------------------------------------------------
Life: porridge would be just right for each universe p1002
Ian Stewart
doi:10.1038/4441002b
Full Text | PDF (77K)
--------------------------------------------------------------------------------
Biography of Crick aims to inspire a wider audience p1002
Michael Ashburner, Mark Bretscher and Peter A. Lawrence
doi:10.1038/4441002c
Full Text | PDF (77K)
--------------------------------------------------------------------------------
Shellfish view of omega-3 and sustainable fisheries p1002
Anthony Robson
doi:10.1038/4441002d
Full Text | PDF (77K)
--------------------------------------------------------------------------------
Top of pageCommentary
Measures for measures p1003
Are some ways of measuring scientific quality better than others? Sune Lehmann, Andrew D. Jackson and Benny E. Lautrup analyse the reliability of commonly used methods for comparing citation records.
doi:10.1038/4441003a
Full Text | PDF (276K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
Top of pageBooks and Arts
The ambiguity is the essence p1005
When we consider the Universe, are we trying to impose order on a meaningless jumble?
Alan Lightman reviews The Human Touch: Our Part in the Creation of a Universe by Michael Frayn
doi:10.1038/4441005a
Full Text | PDF (397K)
--------------------------------------------------------------------------------
The beginning of wisdom p1006
Stuart Ross Taylor reviews Is Pluto a Planet? A Historical Journey Through the Solar System by David A. Weintraub
doi:10.1038/4441006a
Full Text | PDF (425K)
--------------------------------------------------------------------------------
The next pandemic p1007
John Oxford reviews Bird Flu: A Virus of Our Own Hatching by Michael Greger
doi:10.1038/4441007a
Full Text | PDF (507K)
--------------------------------------------------------------------------------
Science in culture p1008
The snowflake man
Martin Kemp
doi:10.1038/4441008a
Full Text | PDF (309K)
--------------------------------------------------------------------------------
Top of pageNews and Views
Physiology: Obesity and gut flora p1009
The intestinal bacteria in obese humans and mice differ from those in lean individuals. Are these bacteria involved in how we regulate body weight, and are they a factor in the obesity epidemic?
Matej Bajzer and Randy J. Seeley
doi:10.1038/4441009a
Full Text | PDF (392K)
See also: Editor's summary
--------------------------------------------------------------------------------
Astrophysics: A burst of new ideas p1010
Gigantic cosmological -ray bursts have fallen into a dichotomy of long and short bursts, each with a very different origin. The discovery of an oddball burst calls for a rethink of that classification.
Bing Zhang
doi:10.1038/4441010a
Full Text | PDF (173K)
See also: Editor's summary
--------------------------------------------------------------------------------
Neurobiology: Auditory fidelity p1013
Detailed investigation of a molecule involved in an inherited type of deafness reveals a fresh facet to the mammalian auditory system — a hitherto unknown way for synapses to put calcium in a bind.
Thomas D. Parsons
doi:10.1038/4441013a
Full Text | PDF (857K)
--------------------------------------------------------------------------------
Particle Physics: Neutrons radiating decay p1014
That neutrons can be transmuted to protons, electrons and antineutrinos through the process of beta decay is old hat. That photons sometimes also get in on the act was suspected, but until now never confirmed.
Nathal Severijns
doi:10.1038/4441014a
Full Text | PDF (440K)
See also: Editor's summary
--------------------------------------------------------------------------------
Ageing: Too fast by mistake p1015
The intricate process of ageing involves numerous physiological pathways, together with genetic and environmental factors. Insight into this complex biology could come from studying a disorder that accelerates ageing.
Tom Kirkwood
doi:10.1038/4441015a
Full Text | PDF (221K)
See also: Editor's summary
--------------------------------------------------------------------------------
Optics: A light touch p1017
Richard Webb
doi:10.1038/4441017a
Full Text | PDF (168K)
--------------------------------------------------------------------------------
Mathematics: Proof at a roll of the dice p1018
The PCP theorem encapsulates the idea that randomization allows the immediate verification of any mathematical proof. A simple route to this striking result was proposed earlier this year.
Bernard Chazelle
doi:10.1038/4441018a
Full Text | PDF (229K)
--------------------------------------------------------------------------------
50 & 100 Years Ago p1019
doi:10.1038/4441019b
Full Text | PDF (125K)
--------------------------------------------------------------------------------
Structural biology: Dangerous liaisons on neurons p1019
Crystal structures show that botulinum toxins bind simultaneously to two sites on neurons. This dual interaction allows them to use a Trojan-horse strategy to enter nerve terminals, with deadly effect.
Giampietro Schiavo
doi:10.1038/nature05410
Full Text | PDF (647K)
See also: Editor's summary
--------------------------------------------------------------------------------
Top of pageBrief Communications
Parthenogenesis in Komodo dragons p1021
Should males and females be kept together to avoid triggering virgin birth in these endangered reptiles?
Phillip C. Watts, Kevin R. Buley, Stephanie Sanderson, Wayne Boardman, Claudio Ciofi and Richard Gibson
doi:10.1038/4441021a
First paragraph | Full Text | PDF (291K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
Microbial ecology: Human gut microbes associated with obesity p1022
Ruth E. Ley, Peter J. Turnbaugh, Samuel Klein and Jeffrey I. Gordon
doi:10.1038/4441022a
First paragraph | Full Text | PDF (234K) | Supplementary information
See also: Editor's summary | News and Views by Bajzer & Seeley
--------------------------------------------------------------------------------
Biomechanics: Rubber bands reduce the cost of carrying loads p1023
Lawrence C. Rome, Louis Flynn and Taeseung D. Yoo
doi:10.1038/4441023a
First paragraph | Full Text | PDF (315K) | Supplementary information
--------------------------------------------------------------------------------
Olfaction: Underwater 'sniffing' by semi-aquatic mammals p1024
Kenneth C. Catania
doi:10.1038/4441024a
First paragraph | Full Text | PDF (455K) | Supplementary information
--------------------------------------------------------------------------------
Top of pageArticles
An obesity-associated gut microbiome with increased capacity for energy harvest p1027
Peter J. Turnbaugh, Ruth E. Ley, Michael A. Mahowald, Vincent Magrini, Elaine R. Mardis and Jeffrey I. Gordon
doi:10.1038/nature05414
Abstract | Full Text | PDF (228K) | Supplementary information
See also: Editor's summary | News and Views by Bajzer & Seeley
--------------------------------------------------------------------------------
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis p1032
Irene Noguera-Troise, Christopher Daly, Nicholas J. Papadopoulos, Sandra Coetzee, Pat Boland, Nicholas W. Gale, Hsin Chieh Lin, George D. Yancopoulos and Gavin Thurston
doi:10.1038/nature05355
Abstract | Full Text | PDF (1,536K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis p1038
Laura J. Niedernhofer, George A. Garinis, Anja Raams, Astrid S. Lalai, Andria Rasile Robinson, Esther Appeldoorn, Hanny Odijk, Roos Oostendorp, Anwaar Ahmad, Wibeke van Leeuwen, Arjan F. Theil, Wim Vermeulen, Gijsbertus T. J. van der Horst, Peter Meinecke, Wim J. Kleijer, Jan Vijg, Nicolaas G. J. Jaspers and Jan H. J. Hoeijmakers
doi:10.1038/nature05456
Abstract | Full Text | PDF (1,002K) | Supplementary information
See also: Editor's summary | News and Views by Kirkwood
--------------------------------------------------------------------------------
Top of pageLetters
A new -ray burst classification scheme from GRB 060614 p1044
N. Gehrels, J. P. Norris, S. D. Barthelmy, J. Granot, Y. Kaneko, C. Kouveliotou, C. B. Markwardt, P. Mészáros, E. Nakar, J. A. Nousek, P. T. O'Brien, M. Page, D. M. Palmer, A. M. Parsons, P. W. A. Roming, T. Sakamoto, C. L. Sarazin, P. Schady, M. Stamatikos and S. E. Woosley
doi:10.1038/nature05376
First paragraph | Full Text | PDF (383K)
See also: Editor's summary | News and Views by Zhang
--------------------------------------------------------------------------------
No supernovae associated with two long-duration -ray bursts p1047
Johan P. U. Fynbo, Darach Watson, Christina C. Thöne, Jesper Sollerman, Joshua S. Bloom, Tamara M. Davis, Jens Hjorth, Páll Jakobsson, Uffe G. Jørgensen, John F. Graham, Andrew S. Fruchter, David Bersier, Lisa Kewley, Arnaud Cassan, José María Castro Cerón, Suzanne Foley, Javier Gorosabel, Tobias C. Hinse, Keith D. Horne, Brian L. Jensen, Sylvio Klose, Daniel Kocevski, Jean-Baptiste Marquette, Daniel Perley, Enrico Ramirez-Ruiz, Maximilian D. Stritzinger, Paul M. Vreeswijk, Ralph A. M. Wijers, Kristian G. Woller, Dong Xu and Marta Zub
doi:10.1038/nature05375
First paragraph | Full Text | PDF (163K) | Supplementary information
See also: Editor's summary | News and Views by Zhang
--------------------------------------------------------------------------------
An enigmatic long-lasting -ray burst not accompanied by a bright supernova p1050
M. Della Valle, G. Chincarini, N. Panagia, G. Tagliaferri, D. Malesani, V. Testa, D. Fugazza, S. Campana, S. Covino, V. Mangano, L. A. Antonelli, P. D'Avanzo, K. Hurley, I. F. Mirabel, L. J. Pellizza, S. Piranomonte and L. Stella
doi:10.1038/nature05374
First paragraph | Full Text | PDF (205K) | Supplementary information
See also: Editor's summary | News and Views by Zhang
--------------------------------------------------------------------------------
A novel explosive process is required for the -ray burst GRB 060614 p1053
A. Gal-Yam, D. B. Fox, P. A. Price, E. O. Ofek, M. R. Davis, D. C. Leonard, A. M. Soderberg, B. P. Schmidt, K. M. Lewis, B. A. Peterson, S. R. Kulkarni, E. Berger, S. B. Cenko, R. Sari, K. Sharon, D. Frail, D.-S. Moon, P. J. Brown, A. Cucchiara, F. Harrison, T. Piran, S. E. Persson, P. J. McCarthy, B. E. Penprase, R. A. Chevalier and A. I. MacFadyen
doi:10.1038/nature05373
First paragraph | Full Text | PDF (237K) | Supplementary information
See also: Editor's summary | News and Views by Zhang
--------------------------------------------------------------------------------
A deep dynamo generating Mercury's magnetic field p1056
Ulrich R. Christensen
doi:10.1038/nature05342
First paragraph | Full Text | PDF (1,512K)
See also: Editor's summary
--------------------------------------------------------------------------------
Observation of the radiative decay mode of the free neutron p1059
Jeffrey S. Nico, Maynard S. Dewey, Thomas R. Gentile, H. Pieter Mumm, Alan K. Thompson, Brian M. Fisher, Isaac Kremsky, Fred E. Wietfeldt, Timothy E. Chupp, Robert L. Cooper, Elizabeth J. Beise, Kristin G. Kiriluk, James Byrne and Kevin J. Coakley
doi:10.1038/nature05390
First paragraph | Full Text | PDF (261K)
See also: Editor's summary | News and Views by Severijns
--------------------------------------------------------------------------------
Fortnightly variations in the flow velocity of Rutford Ice Stream, West Antarctica p1063
G. Hilmar Gudmundsson
doi:10.1038/nature05430
First paragraph | Full Text | PDF (1,054K)
See also: Editor's summary
--------------------------------------------------------------------------------
Intrasexual competition and sexual selection in cooperative mammals p1065
T. H. Clutton-Brock, S. J. Hodge, G. Spong, A. F. Russell, N. R. Jordan, N. C. Bennett, L. L. Sharpe and M. B. Manser
doi:10.1038/nature05386
First paragraph | Full Text | PDF (236K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
Axonal site of spike initiation enhances auditory coincidence detection p1069
Hiroshi Kuba, Takahiro M. Ishii and Harunori Ohmori
doi:10.1038/nature05347
First paragraph | Full Text | PDF (2,074K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
Early events in the thymus affect the balance of effector and regulatory T cells p1073
Daniel J. Pennington, Bruno Silva-Santos, Tobias Silberzahn, Mónica Escórcio-Correia, Martin J. Woodward, Scott J. Roberts, Adrian L. Smith, P. Julian Dyson and Adrian C. Hayday
doi:10.1038/nature05368
First paragraph | Full Text | PDF (671K) | Supplementary information
--------------------------------------------------------------------------------
The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA p1078
Qiaozhen Ye, Robert M. Krug and Yizhi Jane Tao
doi:10.1038/nature05379
First paragraph | Full Text | PDF (905K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis p1083
John Ridgway, Gu Zhang, Yan Wu, Scott Stawicki, Wei-Ching Liang, Yvan Chanthery, Joe Kowalski, Ryan J. Watts, Christopher Callahan, Ian Kasman, Mallika Singh, May Chien, Christine Tan, Jo-Anne S. Hongo, Fred de Sauvage, Greg Plowman and Minhong Yan
doi:10.1038/nature05313
First paragraph | Full Text | PDF (779K) | Supplementary information
See also: Editor's summary
--------------------------------------------------------------------------------
Essential role for collectrin in renal amino acid transport p1088
Ursula Danilczyk, Renu Sarao, Christine Remy, Chahira Benabbas, Gerti Stange, Andreas Richter, Sudha Arya, J. Andrew Pospisilik, Dustin Singer, Simone M. R. Camargo, Victoria Makrides, Tamara Ramadan, Francois Verrey, Carsten A. Wagner and Josef M. Penninger
doi:10.1038/nature05475
First paragraph | Full Text | PDF (680K) | Supplementary information
--------------------------------------------------------------------------------
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity p1092
Rongsheng Jin, Andreas Rummel, Thomas Binz and Axel T. Brunger
doi:10.1038/nature05387
First paragraph | Full Text | PDF (772K) | Supplementary information
See also: Editor's summary | News and Views by Schiavo
--------------------------------------------------------------------------------
Structural basis of cell surface receptor recognition by botulinum neurotoxin B p1096
Qing Chai, Joseph W. Arndt, Min Dong, William H. Tepp, Eric A. Johnson, Edwin R. Chapman and Raymond C. Stevens
doi:10.1038/nature05411
First paragraph | Full Text | PDF (890K) | Supplementary information
See also: Editor's summary | News and Views by Schiavo
--------------------------------------------------------------------------------
Top of pageNaturejobs
Prospect
Prospects p1101
NIH programme offers possibilities of independence for young researchers.
Paul Smaglik
doi:10.1038/nj7122-1101a
Full Text | PDF (159K)
--------------------------------------------------------------------------------
Top of pageFutures
Hotdogs at the end of the world p1104
So long, and thanks for all the sausages.
Jeff Crook
doi:10.1038/4441104a
Full Text | PDF (134K)
上一篇：2006年12月22日 Science中英文摘要 下一篇：权威期刊《科学》杂志质疑台一大学教授论文造假
|
|
|
2006年12月22日 Science中