Methods in Molecular Biology VOLUME209

Transgenic Mouse-Methods and Protocols转基因鼠 实验方法

Edited by Marten H. Hofker, Jan van Deursen

2002 Humana Press Inc.

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Table of Contents 
1.   Introduction: The Use of Transgenic Mice in Biomedical Research
Hofker, Marten H.
pp. 01-08
2.   Genetic Modifi cation of the Mouse: General Technology; Pronuclear and Blastocyst Injection
Voncken, J. Willem
pp. 09-34
3.   In Vitro Fertilization/Cryopreservation
Marschall, Susan; de Angelis, Martin Hrabe
pp. 35-50
4.   Transgene Design
Voncken, J. Willem
pp. 51-68
5.   Generating Conditional Mouse Mutants via Tetracycline-Controlled Gene Expression
Sch鰊ig, Kai; Bujard, Hermann
pp. 69-104
6.   Manipulating Large Insert Clones for Transgenesis
McCormick, Sally P. A.; Liu, Catherine Y. Y.; Young, Stephen G.; Nielsen, Lars B.
pp. 105-124
7.   Reporter Molecules in Genetically Engineered Mice
Saunders, Thomas L.
pp. 125-144
8.   Gene Targeting in Mouse Embryonic Stem Cells
van Deursen, Jan
pp. 145-158
9.   Conditional Knockout Mice
K黨n, Ralf; Schwenk, Frieder
pp. 159-186
10.   Knockin Approaches
Roebroek, Anton J. M.; Wu, Xiaosheng; Bram, Richard J.
pp. 187-200
11.   Aggregation of Embryos and Embryonic Stem Cells
Maatman, Ronald; Gertsenstein, Marina; Meijer, Emile de; Nagy, Andras; Vintersten, Kristina
pp. 201-230
12.   Adenovirus-Mediated Gene Transfer
van Dijk, Ko Willems; Kypreos, Kyriakos E.; D'Oliveira, Christine; Fallaux, Frits J.
pp. 231-248
13.   Random ENU Mutagenesis
Soewarto, Dian; Blanquet, V閞onique; de Angelis, Martin Hrabe
pp. 249-266
14.   Autopsy and Histologic Analysis of the Transgenic Mouse
Gijbels, Marion J. J.; de Winther, Menno P. J.
pp. 267-280
15.   Bone Marrow Transplantations to Study Gene Function in Hematopoietic Cells
de Winther, Menno P. J.; Heeringa, Peter
pp. 281-292
16.   Quantification of Atherosclerosis in Mice
Daugherty, Alan; Whitman, Stewart C.
pp. 293-310
17.   Genetically Modified Mice in Cancer Research
Largaespada, David A.
pp. 311-332
18.   Neuropathobiology in Transgenic Mice: The Case of Alzheimer's Disease
Dorpe, Jo Van; Spittaels, Kurt; den Haute, Chris Van; Dewachter, Ilse; Moechars, Dieder; Geerts, Hugo; Leuven, Fred Van
pp. 333-362